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n 1104 Euro Intervention 2012;7: 1103-1110 Introduction Metformin, a biguanide, was introduced in 1957 for the treatment of non-insulin dependent diabetes mellitus 1.

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Effect of Combination Glipizide GITS/Metformin on Fibrinolytic and Metabolic Parameters in Poorly Controlled Type 2. Results of a Multicentre Clinical Trial.Update on Cardiovascular Outcome Trials in Diabetes Rury R. Holman,. Results expected 2018. Trial Treatment Inclusion criteria Primary endpoint Number of.A Trial in Progress: Gestational Diabetes: Treatment with metformin compared with insulin (the Metformin in Gestational Diabetes [MiG] trial) Diabetes Care.